The United States Secretary of Commerce and Labor was the head of the short-lived United States Department of Commerce and Labor, which was concerned with business, industry, and labor. The secretary was a member of the President's Cabinet. In 1913 there was a division of the Secretary's position into separate positions of Commerce and Labor.

The list of Secretaries continues at United States Secretary of Commerce and United States Secretary of Labor.

v • d • e United States Secretaries of Labor Secretaries of Commerce & Labor Cortelyou • Metcalf • Straus • Nagel Secretaries of Labor Wilson • Davis • Doak • Perkins • Schwellenbach • Tobin • Durkin • Mitchell • Goldberg • Wirtz • Shultz • Hodgson • Brennan • Dunlop • Usery • Marshall • Donovan • Brock • McLaughlin • Dole • Martin • Reich • Herman • Chao

v • d • e United States Secretaries of Commerce Secretaries of Commerce & Labor: Cortelyou • Metcalf • Straus • Nagel Secretaries of Commerce: Redfield • Alexander • Hoover • Whiting • Lamont • Chapin • Roper • Hopkins • Jones • Wallace • Harriman • Sawyer • Weeks • Strauss • Mueller • Hodges • Connor • Trowbridge • Smith • Stans • Peterson • Dent • Morton • Richardson • Kreps • Klutznick • Baldrige • Verity • Mosbacher • Franklin • Brown • Kantor • Daley • Mineta • Evans • Gutierrez